Abstract

A REVIEW ARTICLE ON POLYMERIC PRODRUG

*Ms. Vaishnavi Bhakare, Mr. Pratik Kachare, Ms. Aakanksha Mane, Mr. Sharad Patil, Mr. Pankaj Kalel, Dr. Nagesh Aloorkar

ABSTRACT

A model for the logical design of polymeric prodrugs was put up by Prof. H. Ringsdorf in 1975 [J. Polym. Sci. Symp. 51 (1975) 135]. Since it was the first model to consider both the chemical and biological features required for the creation of polymeric prodrugs, it has been the most significant foundation for research in the subject. The most significant characteristics that were found through the creation of polymeric prodrugs are discussed in this paper: the drug's prolonged action, regulated release, passive tumor buildup through the EPR-effect, and modification of body distribution and cell uptake. Other goals have been developed over time, and new characteristics of polymer-drug conjugates have been identified. This work provides a more thorough description of one recent example, the immunoprotective potential of polymeric prodrugs. One extremely practical type of drug delivery agents is polymericprodrugs. For uses ranging from controlled release to passive drug targeting, a variety of polymeric prodrugs have been developed. However, the releasing processes' mechanical elements have not been precisely defined. The key elements of the chemical reactions that cause drug release from various systems are highlighted in this review. There is discussion of the release mechanisms from polymeric prodrugs that use amides, carbamates, carbonates, esters, C––N links, and other chemical linkages. The American Pharmacists Association and Wiley-Liss, Inc., 2004 J Pharm Sci 93:1962–1979

Keywords: polymeric prodrugs, Controlled drug release, Drug delivery systems, Polymer–drug conjugates.