Abstract

COMPATIBILITY STUDIES OF CHLORHEXIDINE WITH PHARMACEUTICAL EXCIPIENTS FOR THE DEVELOPMENT OF GEL NOVEL DRUG DELIVERY SYSTEMS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif, Maged Alwan Noman, Sami Ahmed Saeed

ABSTRACT

Chlorhexidine is a synthetic cationic bis-biguanide compound used as a topical antiseptic. It is classified as a broad-spectrum antimicrobial agent with potent bactericidal and bacteriostatic activity against Gram-positive and Gram-negative bacteria. Emulgel, combining the hydrophilic properties of gels with the biphasic structure of emulsions, offer enhanced solubility, stability, controlled release, and mucosal penetration. Additionally, Gels further offer ease of application, high spreadability, and good patient acceptability. Clove oil, a natural analgesic, anti-inflammatory, and antimicrobial agent, also improves taste, promoting better compliance. The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Chlorhexidine Hydrogel and Emulgel NDDS for topical application. In the present study that the compatibility was assessed by, FTIR spectroscopy and preformulation parameters. Results showed that physical mixtures of Chlorhexidine and various excipients such as Carbopol, Chlorhexidine is a synthetic cationic bis-biguanide compound used as a topical antiseptic. It is classified as a broad-spectrum antimicrobial agent with potent bactericidal and bacteriostatic activity against Gram-positive and Gram-negative bacteria. Emulgel, combining the hydrophilic properties of gels with the biphasic structure of emulsions, offer enhanced solubility, stability, controlled release, and mucosal penetration. Additionally, Gels further offer ease of application, high spreadability, and good patient acceptability. Clove oil, a natural analgesic, anti-inflammatory, and antimicrobial agent, also improves taste, promoting better compliance. The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Chlorhexidine Hydrogel and Emulgel NDDS for topical application. In the present study that the compatibility was assessed by, FTIR spectroscopy and preformulation parameters. Results showed that physical mixtures of Chlorhexidine and various excipients such as Carbopol,

Keywords: Chlorhexidine, NDDS, Compatibility, Excipients, Development, Preformulation, Hydrogel, Emulgel.