Abstract

SOLUBILITY AND DISSOLUTION ENHACEMENT OF ZIPRASIDONE BY BINARY AND TERNARY SOLID DISPERSION

Mallikarjun Hindinmani*, Navya H. K., Abhishek C. Pasarad, Ramya M. Talawar, Vinayak M. Baligar, Aishwarya L. Shetter

ABSTRACT

Objective: The objective of this research was to improve the solubility and dissolution rate of Ziprasidone by binary and ternary solid dispersion technique. Methods: Solid dispersions were prepared by physical mixture and solvent evaporation in the binary and ternary system. In binary system Ziprasidone was mixed with PEG 6000 in the ratio of 1:1, 1:2 and 1:3 and with β-Cyclodextrin in 1:1, 1:2 and 1:3 ratio. In ternary system Ziprasidone was prepared with PEG 6000 and β-Cyclodextrin in the ratio of 1:1:1, 1:2:1, 1:3:1, 1:1:2 and 1:1:3. Pure Ziprasidone, solid dispersions, and physical mixtures were characterized by FT-IR, drug content and dissolution testing. Results: FTIR studies confirm that there was no interaction between drug and carriers used in the preparation of solid dispersion. The results of drug content uniformity study show the uniform dispersion of Ziprasidone throughout the formulation. Preparation of ternary solid dispersion enhancedthe dissolution of the drug compared to the pure drug and binary system. Among the various formulations prepared, Dissolution efficiency with formulation (T5) was higher than that obtained with binary solid dispersions containing the same proportion of either PEG or β-cyclodextrin. Conclusion: Overall the results of research work reveals that when Ziprasidone was formulated as an ternary system shows higher solubility, faster dissolution rate, which may enhances the bioavailability.

Keywords: Ziprasidone, Solid dispersions, PEG 6000, ?-Cyclodextrin.