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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

FORMULATION AND EVALUATION OF GINGEROL AS VESICULAR DRUG DELIVERY SYSTEMS (NIOSOMES) USING REVERSE-PHASE EVAPORATION TECHNIQUE

N. Poojitha, K. Swathi Priya, Ch. Kesari3, P. Prathyusha, K. Charan Sai

ABSTRACT

This study aimed to formulate and evaluate niosomal drug delivery systems containing 6-gingerol, a bioactive compound known for its anti-cancer properties. Using reverse-phase evaporation technique, eight formulations (F1-F8) were developed employing varying combinations of non-ionic surfactants (Span 80, Tween 20, and Tween 80) and cholesterol. The formulations were assessed for encapsulation efficiency, vesicle size, shape, and in-vitro drug release. Results indicated that formulations with higher molecular weight surfactants exhibited superior encapsulation efficiency and sustained drug release, highlighting their potential as effective delivery systems for 6-gingerol.

Keywords: -gingerol, niosomes, reverse-phase evaporation, encapsulation efficiency, sustained release.

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