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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

A COMPREHENSIVE REVIEW OF ANALYTICAL METHODS FOR THE DETERMINATION OF UPADACITINIB HEMIHYDRATE IN ULCERATIVE COLITIS THERAPY

Meshwa Patel*, Dr. Khushbu Patel, Dr. C. N. Patel, Mrs. Sushila R. Prajapati, Aachal Bhavsar, Jinal Goswam

ABSTRACT

Upadacitinib hemihydrate is a selective Janus kinase-1 (JAK1) inhibitor approved for the treatment of immune-mediated inflammatory diseases, including ulcerative colitis. Due to its oral administration, favorable pharmacokinetics, and targeted action, it is an effective option for patients with moderate to severe disease. Reliable analytical methods are essential for its quality control, stability testing, pharmacokinetic studies, and therapeutic monitoring in bulk drugs, dosage forms, and biological samples. This review summarizes its key properties and highlights reported analytical techniques—mainly HPLC, UPLC, and LC-MS/MS—emphasizing the need for sensitive and validated methods for routine and stability analysis.

Keywords: Ulcerative Colitis, Upadacitinib Hemihydrate, JAK1 Inhibitor, Pharmacokinetics, Analytical Method.

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