Abstract

THERMOSENSITIVE LIPOSOMAL GELS: DESIGN STRATEGIES FOR ENHANCED TOPICAL ANTI-INFLAMMATORY DELIVERY

Mamatha G. T., R. Sharan*, Partiban S., Srinivas H. C., Sindhu S.

ABSTRACT

Thermosensitive liposomal gel platforms offer an advanced strategy for topical delivery of anti-inflammatory agents like curcumin, overcoming challenges of poor solubility, stability, and bioavailability inherent in conventional formulations. This review examines their design and performance, integrating thermosensitive liposomes—typically dipalmitoyl phosphatidylcholine (DPPC)-based with phase transitions at skin temperatures into in situ gelling matrices such as Carbopol, chitosan, or Pluronic. Prepared via thin-film hydration or extrusion, these systems exhibit optimal properties particle size, PDI, negative zeta potential, and encapsulation efficiency for drug delivery. Ex vivo and In vitro studies demonstrate superior skin retention, sustained release (e.g., 60% over 24 hours versus rapid free-drug release), and dermal accumulation via temperature-triggered bilayer disruption and sol-gel transitions, minimizing systemic exposure. Anti- inflammatory efficacy excels in models, reducing edema and markers through prolonged residence and controlled dosing. Techniques like FTIR, DSC, and rheology confirm compatibility, thermosensitivity, and non-irritancy. Challenges include scalability and stability, but tabulated studies affirm trends in enhanced penetration. Future efforts target multi-stimuli responsiveness and clinical trials for inflammatory disorders.

Keywords: Thermosensitive liposomes, liposomal gels, curcumin, anti-inflammatory, Hydrogel.