Abstract

ANTICONVULSANT POTENTIAL OF CRASSULA OVATA: IN VIVO ASSESSMENT OF SEIZURE MODULATION, NEUROCHEMICAL RESTORATION, AND BEHAVIOURAL PHARMACOLOGY IN PTZ-TREATED RATS

*Satheesh Kumar N., Dr. S. Kannan, Dr. B. Sangameswaran

ABSTRACT

The present investigation evaluates the anticonvulsant potential of Crassula ovata through an integrated approach involving in vitro antioxidant assays, acetylcholinesterase (AChE) inhibition, and in vivo PTZ-induced seizure models in albino rats. The extract exhibited strong DPPH radical scavenging activity and moderate AChE inhibition in vitro, indicating the presence of bioactive constituents with neuroprotective potential. In vivo administration of PTZ produced rapid seizure onset, elevated seizure scores, and altered neurochemical levels. Treatment with C. ovata (200 mg/kg and 400 mg/kg) significantly delayed seizure onset, reduced seizure severity, restored dopamine levels, and modulated brain AChE activity compared to the PTZ group. These findings support the potential anticonvulsant and neurochemical-stabilizing properties of C. ovata, suggesting its suitability for further exploration as a natural therapeutic candidate for epilepsy.

Keywords: Crassula ovata; PTZ-induced seizures; antioxidant activity; acety lcholinesterase inhibition; dopamine modulation; anticonvulsant effect.