Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS FEBRUARY ISSUE PUBLISHED
  • FEBRUARY 2020 Issue has been successfully launched on 1 February 2020.

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Abstract

HEPATOPROTECTIVE EFFECT OF ARTICHOKE LEAVES AQUEOUS EXTRACT IN CCL4 INTOXICATED RATS

Shalaby, M. A.* and Hammoda, A.A.

ABSTRACT

The phytochemical screening of Artichoke leaves aqueous extract (ALE) was undertaken and its protective effect against carbon tetrachloride (CCL4)-induced hepatotoxicity in rats was studied. Fifty mature male rats were randomized into 5 equal groups as follows: (1) negative (normal) control, (2) positive (intoxicated non-treated) control, (3) standard (Silymarin-pretreated, 50 mg/kg), (4) pretreated with ALE in dose 200 mg/kg and (5) pretreated with ALE in dose 400 mg/kg, respectively. CCL4 was subcutaneously injected to all groups except the negative control during the last week of experiment to induce hepatotoxicity. Silymarin and ALE were orally given to rats in daily doses for 6 weeks. At the end of experiment, rats were weighed, sacrificed and blood samples were collected for serum biochemical analyses. Livers of the sacrificed rats were taken for assaying activities of antioxidant enzymes and histopathology. The phytochemical screening revealed that ALE contains flavonoids, saponins, alkaloids, tannins, glycosides, and devoid of resins and triterpenes. Oral pretreatments with ALE increased body weight gain; normalized serum levels of AST, ALT and ALP enzymes, total cholesterol, triglycerides, low density lipoprotein, and total bilirubin, and increased levels of total proteins. There were also increases in activities of tissue superoxide dismutase, glutathione peroxidase and catalase antioxidant enzymes with mitigation of renal tubular necrosis induced by CCL4 in the liver. These results denote that ALE has hepatoprotective, hypolipidemic and antioxidant effects in hepatotoxic rats. Therefore, intake of Artichoke leaves as herbal tea may be beneficial for patients who suffer from liver diseases.

Keywords: Artichoke, Hepatoprotective, Hypolipidemic, Antioxidant, Liver histopathology.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More