Abstract

FORMULATION AND EVALUATION OF POLYHERBAL TABLETS FOR ANTIDIABETIC ACTIVITY

M. Santhosh Kumar, S. Sathish, T. Sathish, V. Sathish Kumar, T. Senthil, N. Rajasekar*

ABSTRACT

Polyherbal formulations have gained significant importance due to their synergistic therapeutic effects and improved safety profile. The present study aimed to formulate and evaluate polyherbal tablets containing s elected medicinal plants traditionally used for the management of diabetes mellitus. The polyherbal blend was prepared using Psidium guajava , Moringa oleifera , Ocimum sanctum , Cinnamomum zeylanicum , and Cucurbita pepo , and tablets were formulated by direct compression method using suitable pharmaceutical excipients. The prepared tablets were evaluated for physicochemical parameters including weight variation, hardness, friability, disintegration time, drug content uniformity, and in vitro drug release studi es according to pharmacopoeial standards. The results demonstrated that all evaluation parameters were within acceptable limits, indicating good mechanical strength, uniformity, and satisfactory release characteristics. The optimized formulation exhibited a consistent in vitro drug release profile, supporting its suitability for oral administration. The study concludes that the developed polyherbal tablet formulation is pharmaceutically acceptable and holds potential as an effective antidiabetic herbal dos age form.

Keywords: Diabetes mellitus, Polyherbal formulation, Mucoadhesive buccal tablet, Controlled release, Psidium guajava, Antidiabetic activity