Abstract

AN OVERVIEW OF NANOLIPOSOMES AS SMART DRUG DELIVERY CARRIERS – CURRENT STATUS

Sonal Janrao*, Anjali Suryawanshi, Sucheta Dilip Bhise, Rajkumar V. Shete

ABSTRACT

Nanoliposomes have increased exponentially since their discovery in the 1960s, primarily for encapsulating medicines or compounds that can improve human health. However, recent studies propose nanoliposomes as vehicles to protect, transport, and subsequently release compounds of various kinds to fortify the properties of foods and cause a prolonged release of encapsulated substances in a specific part of the body. Recent nanoliposome research has focused on adding them to foods to enhance and fortify the product’s properties for consumption. Factors determining a successful encapsulation and specific prolonged release include encapsulation efficiency, process yield, prolonged release factor, particle size, and Zeta potential. The liberty of this review is to initiate the concept of nanoliposomes and also elaborate on a few facets and mechanisms of nanoliposomes. Nanoliposome provides extensive value in transdermal drug delivery systems. It indicates that current developments and advancements have increased the therapeutic perspective. Opportunities in nanomedicine are abundant for nanoliposomes, ranging from their use as diagnostic instruments to their use as drug carriers for both topical and systemic therapies. It has significant use for various topical treatments like inflammation, anticancer drug delivery, infections caused by bacteria and fungi, etc. because of its smaller size and larger surface area it was able to permeate in the deeper layer of the skin and finally reach systemic circulation Due to its structural component, it has a superior sustained-release activity that was implied by the capacity to cross skin membranes and blood endothelial  barrier. Nevertheless, the different fabrication methodology of nanoliposomes helps to ensure the size, quality, and stability of the formulation.

Keywords: Nanoliposomes, encapsulation efficiency, prolonged release, process yield, Zeta potential, sustained-release.