Abstract

DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF QUERCETIN SUSPENSION IN MILK THISTLE OIL DISPENSED IN HARD GELATIN CAPSULES

*Hamam Salih Badri Hamam

ABSTRACT

Great number of liver and gastrointestinal diseases together with hepatotoxicity of many synthetic drugs causes an urgency to search new herbal medicines with strong therapeutic action and minimal side effects. Many hepatoprotective drugs, containing as an active component flavolignans extracted from milk thistle seeds, have been developed and manufactured commercially. At the same time oil obtained from this raw material also has hepatoprotective, antiinflammatory, epitelizing and wound-healing action, however it is not used as a medicinal substance and considered as waste in manufacturing of the above-stated preparations. Besides, new trends in pharmacotherapy of liver and gastrointestinal diseases provide application of hepatoprotectors in complex with potent antioxidants, e.g. quercetin that allows to achieve stronger and rapid pharmacological effect as a result of synergic interactions of components Taking above-stated into account development of technology for new hepatoprotective herbal drug. The purpose of this work is development of composition and technology for new herbal drug in form of quercetin suspension in milk thistle oil dispensed into hard gelatin capsules. For capsulation the quercetin suspension containing 0,1 % of span-65, dispergated for 5 minutes with ultrasound at 22 kHz frequency and 3 W / cm2 power was used.

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