Abstract

GASTRORETENSIVE DRUG DELIVERY SYSTEM: AN REVIEW

V. Baby Naga Lakshmi*, B. Yaswanth*, Dr. D. Rama Brahma Reddy*, Ch. N. V. S. Mastan Rao*

ABSTRACT

English oral delivery of drug was the commonly used modality because of patient compliance and ease of administration. After oral administration of any drug, its bioavailability is affected by its residence time in stomach. Recently, gastro retentive drug delivery systems (GRDDS) have gained wide acceptance for drugs with a narrow absorption window, decreased stability at high alkaline pH, and increased solubility at low pH. This approach develops a drug delivery system, which gets retained within gastric fluid, thereby releasing its active principles in the stomach. Some methods used to achieve gastric retention of drugs include the use of effervescence agents, mucoadhesive polymers, magnetic material, bouncy enhancing excipient, and techniques that form plug-like devices that resist gastric emptying. This review provides a concise account of various attributes of recently developed approaches for GRDDS.

Keywords: Gastro retentive, Bioavailability, bio/mucoadhesive system, therapeutic window, gastric emptying, GRDDS.