Abstract

NANO PHARMACEUTICALS IN TARGETED DRUG DELIVERY

*K. Malleswari, Dr. D. Rama Brahma Reddy, M. Ganesh

ABSTRACT

The of large sized materials in drug delivery raises several challenges, including in vivo stability, poor bioavailability/solubility/absorption, and issues with target-specific delivery, in addition to the side effects of the delivered drugs. Therefore, using new drug delivery systems for targeting drugs to a specific area in the body could be an opportunity to solve these critical issues. The area of nanotechnology develops nanoscale-sized materials that consist of natural, synthetic/semisynthetic polymers, lipids, or metallic materials. Nanoparticles [NPS] can be used in targeted drug delivery to improve the bioavailability, biodistribution, and accumulation of therapeutics, preferentially in the targeted diseased area, acting as stability enhancers. These colloidal systems can deliver drugs to target sites to improve therapeutic efficiency, reduce toxicity, and reduce side effects, protecting the drug from biological degradation, achieving temporal and spatial control of therapeutics in the specific location of a disease. The first implementation of nanocarriers for use in drug delivery was based on a passive targeting mechanism that aimed to increase efficiency over traditional free-drug formulations.

Keywords: Understanding nanotechnology in pharmaceuticals, Future outlook, Delivery of anticancer chemothrapeutics.