Abstract

IOHEXOL INDUCED TOXIC EPIDERMAL NECROLYSIS - A RARE CASE REPORT

Dr. Yathish Kumar G.* (Postgraduate), Dr. Deepak P. (Professor and Head)

ABSTRACT

Introduction- Toxic epidermal necrolysis (TEN) is a rare, life-threatening drug-induced skin disease also known as Lyell's syndrome and is a common cause of significant skin and mucous membrane disintegration. Thus, this case of TEN induced by Iohexol has been found to be rare in relevant scientific literature. Case details- An 83-year-old male patient diagnosed with Pancreatic pseudocyst got admitted in HIMS Surgery department 2 months ago and was advised CECT abdomen scan, during which the patient was given Contrast Iohexol. Two days following which the patient developed erythema over the back which gradually extended to axilla and upper limbs. Multiple erosions of various sizes and shapes present on the back and upper limbs and on genitalia with conjunctival congestion and haemorrhagic crests on both eyelids and lips. Provisional diagnosis of Toxic epidermal necrolysis was made by Dermatologist, and patient was put on Inj. dexamethasone, Inj. Chlorphenaramine malate, Tab Cyclosporine and antibiotics (Inj.Piperacillin + Tazobactam). The rashes started to subside after 8 days of supportive treatment. Conclusion: As there are very few reports of iohexol-induced TEN, we present a case of TEN triggered by the non-ionic iodinated contrast medium iohexol, with the aim of improving awareness and helping to prevent iohexol-induced TEN.

Keywords: Iohexol, Adverse drug reaction, Toxic epidermal necrolysis.