Abstract

RECENT ADVANCES IN AEROGEL-BASED SYSTEMS FOR DRUG DELIVERY APPLICATIONS: A COMPREHENSIVE REVIEW

Sethupathi S.*, Manikandan A., Siva S., V. Jeevith Kumar, Suganya K., Dr. Sathish A.

ABSTRACT

This comprehensive review explores recent advances in aerogel-based systems for drug delivery, highlighting their unique structural and physicochemical properties, biocompatibility, and versatile applications. Aerogels, characterized by high surface area, low density, and tunable porosity, offer a promising platform for controlled drug release. The review discusses aerogel synthesis and functionalization techniques to enhance drug loading and targeting capabilities. Mechanisms of drug loading and release, encompassing diffusion, erosion, and swelling, are examined in detail. Various aerogel platforms, such as silica-based, polymer-based, and hybrid aerogels, are compared for their suitability in different administration routes, including oral, pulmonary, transdermal, injectable, and implantable delivery. Applications in treating infectious diseases, regenerative medicine, and ocular conditions are also covered. Furthermore, the review addresses physicochemical characterization techniques, ethical and A environmental aspects, and emerging trends in aerogel- based drug delivery. Despite the significant potential, challenges related to toxicity, biocompatibility, stability, and biodegradability must be addressed to facilitate commercialization and widespread clinical adoption. Future research should focus on these areas to unlock the full potential of aerogels in revolutionizing drug delivery and improving patient outcomes.

Keywords: Aerogel, Physicochemical properties, Drug delivery, Silica based, Biocompatibility.