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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

EFFECT OF AN ISOLATED COMPOUND (AS-1) FROM AMARANTHUS SPINOSUS LINN. LEAVES ON SERUM LIPIDS IN NORMAL AND DIABETIC RATS

Prasanta Kumar Mitra¹*, Tanaya Ghosh¹, Prasenjit Mitra¹, Arabinda Ray², Krishna Chandra Sarker²

¹Department of Biochemistry, 2. Department of Physiology, North Bengal Medical College, Sushrutanagar � 734012. Dist.Darjeeling, West Bengal, India.

ABSTRACT

An active compound (AS-1) was isolated from leaves of Amaranthus spinosus Linn.. The compound was given orally in low (30 mg/kg) and high (60 mg/kg) doses to normal and diabetic rats for two weeks. Diabetes in rats was induced by alloxan. Serum lipids like cholesterol, triglycerides, HDL, LDL and VLDL were estimated. Results showed that the active compound (AS-1) produced a significant fall in serum cholesterol, triglycerides, LDL and VLDL in normal rats. In diabetic rats AS-1 increased HDL cholesterol but decreased the raised levels of serum cholesterol, triglycerides, LDL and VLDL.

Keywords: Amaranthus spinosus Linn., serum lipids, isolated compound (AS-1), alloxan, diabetes.

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