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Abstract

DEVELOPMENT AND EVALUATION OF TIME CONTROLLED PULSATILE DRUG DELIVERY SYSTEM OF KETOPROFEN.

Patel Jitendra*, Dr. Madhabhai Patel, Dr. Anil Bhandari

ABSTRACT

Many disease conditions follow the circardian rhythm. In rheumatoid arthritis maximum pain observed early in the morning. So efforts have been done to delivery the drug, which is administered at the night, delayed the drug release for 6 hrs and release the drug early in the morning. An oral press coated tablet was developed by direct compression method to achieve the time controlled tablet with a distinct predetermined lag time. Press coated tablet containing ketoprofen in the inner core was formulated with outer shell by using hydroxy propyl methyl cellulose and ethylcellulose. The effect of outer coating on lag time was investigated and formulation was modified. The release profile of press coated tablet exhibit that hydroxyl propyl methyl cellulose have lesser effect on lag time, while ethylcellulose have lag time of up to 8 hrs. So formulation was developed by using combination of hydroxyl propyl methyl cellulose and ethylcellulose.

Keywords: Press coated tablet, lag time, Hydroxy propyl methyl cellulose, Ethylcellulose.


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