Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF PRAVASTATIN SOLID DISPERSION TABLETS BY DIRECT COMPRESSION METHOD

*Dr. Govind Reddy G., Dr. K M Manjanna, Ms. V. Radha

ABSTRACT

Background and Objectives: Among all route of administration the oral delivery is well known preferred delivery system for systemic administration of therapeutic agents because of accurate dosage, and easily to administration Pravastatin, a cholesterol-lowering agent, exhibits limited oral bioavailability due to its poor aqueous solubility and dissolution rate. The present study focuses on the design, development, and evaluation of Pravastatin solid dispersion tablets by direct compression method to enhance its dissolution characteristics. Solid dispersions of Pravastatin were prepared using suitable carriers to improve drug solubility and release profile. The formulations were characterized for their solid-state properties using Fourier Transform Infrared Spectroscopy (FTIR) to assess drug–excipient compatibility. The prepared tablets were further evaluated for physicochemical parameters such as hardness, friability, weight variation, uniformity of drug content, and in vitro dissolution studies. Enhanced dissolution performance was expected to improve the therapeutic efficiency of Pravastatin. The use of direct compression method provided a simple, cost-effective, and scalable approach for formulation development. This work highlights the potential of solid dispersion technology as a promising strategy for improving the bioavailability of poorly soluble drugs like Pravastatin.

Keywords: Pravastatin, Oral dispersible tablets, Solid Dispersion Method, Direct Compression, In-vitro drug release, PVP K-30, Crospovidone, and Sodium starch glycolate.