Abstract

REVIEW ON PHOTOSTABILITY STUDIES AND METHODS TO ENHANCE PHOTOSTABILITY

Manasi Kulkarni*, Nida N. Mulla, Sanjay K. Bais

ABSTRACT

In the Quality of medication in which, Photostability of medications and drugs products is a mandatory step in the product development process. The purpose of these investigations is to guarantee the formulated products' safety, effectiveness, and quality during production, storage, andusage. The notion of photostability, associated elements, and the body of literature in the topic are all covered in this review. It discusses the kinetics of photochemical reactions, defines photophysical processes, outlines the functional groups crucial to drug photoreactivity, and emphasizes the relevance of photochemistry in photostability investigations. The ICH guideline's standards and the photostability assessment of medications are enlisted. There are guidelines given on the labelling of formulations. Also covered are the several techniques for photostabilizing liquid and solid dosage forms. The problem of photostability in drugs is examined and ways to increase photostability in formulation. This review addresses formulation properties that affect photostability, variables affecting photostability, and the mechanism of photo-degradation with examples.

Keywords: Photostability, Photoreactions, Degradation, Packaging, Effectiveness.