Abstract

FORMULATION AND EVALUATION OF TABLET CONTAINING UNRIPE FRUIT EXTRACT OF SOLANUM NIGRUM L. IN CHEWABLE FORM

Bhavanasi Glady Sahithi*, Mrs. J. Bharathi, Dr. K. Umasankar, Dr. M. Kishore Babu

ABSTRACT

The purpose of this research work is to formulate and evaluate chewable tablets by using Solanum nigrum L. Unripe fruit extract that disintegrates in the mouth and provide an effective treatment for glossitis. The present work is the phytochemical screening of the ethanolic extract the plant Solanum nigrum, followed by pre-formulation studies like organoleptic properties, solubility, compatibility studies by FTIR, and calibration studies using UV spectroscopy. These studies aimed to develop a chewable tablet formulation using the direct comparison method with various compositions. The studies of the chewable tablets are pre-compression parameters like angle of repose, bulk density, taped density, Carr’s index, and Hausner ratio, and post-compression parameters like appearance, thickness, hardness test, friability test, weight variation test, disintegration test, and stability studies. Finally, all parameters are within the limit. So, the stability study of Formulation F2 revealed that the plant extract of Solanum nigrum was stable under accelerated and intermediate stability conditions for 3 months. Hence, Formula F2, containing the plant extract of Solanum nigrum at 650 mg, has been formulated as a chewable tablet by the direct compression method, which satisfied all the criteria for chewable tablets. Hence, it may be summarized that the tablets prepared by the direct compression method might be a perfect and effective formulation to prevent the treatment of glossitis.

Keywords: Solanum nigrum L. Unripe fruit, Chewable tablet Form, Ethanolic extract, Characterization, FTIR, UV, Stability Studies, Pre-formulation Studies, post- formulation Studies, Stability studies, Glossitis.