Abstract

DIAGNOSTIC APPROCH ON ALZHEIMER’S DISEASE

Miss. Akanksha Wasudeorao Bhute*, Miss. Lochani S. Gajbhiye, Miss. Khushi S. Kothari, Prof. Vishnudas Lokhande, Dr. Rahul Bijwar

ABSTRACT

Alzheimer’s disease is the most common type of dementia, characterized by a progressive decline in cognitive function, particularly memory and impacting daily life. It is a neurodegenerative disorder involving the abnormal build-up of proteins in the brain forming plaques. These protein aggregates and disrupt normal brain cell function leading to neuron damage. It is an undertreated and under-recognized disease that is becoming a major public health problem. The last decade has witnessed a steadily increasing effort directed at discovering the aetiology of the disease and developing pharmacological treatment. This disease starts after the age of 55-60 but in down syndrome patients it starts earlier at the age of 40-50. Some of the chemicals used as inducing agents are scopolamine, colchicine, Okadaic acid, Trimethyl tin and some of the metal ions are used in animal models. Alzheimer’s disease is similarto that of coronary heart disease or ischemic. Background: - It was first described in 1906 by Dr. Alois Alzheimer, after studying a patient named Auguste D, who exhibited symptoms like memory loss and language problem.

Keywords: Alzheimer’s disease, cognitive impairment, loss of memory, tau protein, beta amyloid, oxidative stress.