Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF 3-[4-{2-(SUBSTITUTEDPHENYL)-4-OXO-1, 3- THIAZOLIDIN-3-YL}PHENYL] -6-BROMO-2- PHENYLQUINAZOLIN-4-ONE.

Deepa Gor and Pankaj S. Patel*

ABSTRACT

Heterocyclic Compounds have so far been synthesized mainly due to the wide range of biological activities. Thiazolidinone plays an important role in biological field. From these reviews we synthesized a new series of 3-[4-{2-(substituted phenyl)-4-oxo-1,3-thiazolidin-3- yl}phenyl]-6-bromo-2-phenylquinazolin-4-one derived from cycloaddition cyclization method of Schiff base in presence of ZnCl2 with thioglycolic acid is developed. The title compounds were characterized by element analysis, IR, NMR and spectral data. All the compounds were tested for their antibacterial and antifungal activities by Cup Borer method.

Keywords: Thiazolidinone, IR, NMR, Cup Borer method.