Abstract

DOXORUBICIN HYDROCHLORIDE USED FOR THE TREATMENT OF BREAST CANCER

Jyotsna Rajendra Nagargoje, Asst. Pr. Priyanka Gadankush

ABSTRACT

Breast cancer's still a huge health issue globally, accounting for nearly 30% of all new cancer cases diagnosed in women each year. This article digs into doxorubicin hydrochloride, a chemo drug based on anthracyclines that's got some serious stuff going on that has been a big deal in treating breast cancer since the '60s. It digs into the drug's molecular stuff. The action's got clinical uses and it's still a big deal in today's cancer treatments. The study breaks down how doxorubicin HCl messes with DNA and stops a key enzyme topoisomerase II, the dynamic duo that's basically the cancer-zapping heroes of the cell world It also chats about fresh stuff targeted delivery methods to up the drug's power and keep the side effects low. The study revealed some nasty side effects of breast cancers on the rise, especially in the younger crowd of women—getting thelowdown on how doxorubicin HCl works and what it means for treatment essential for improving treatment outcomes and patient care. Cancerstats Drugbank.

Keywords: Doxorubicin Hydrochloride; Anthracycline; Breast Cancer; DNA Intercalation; Topoisomerase II Inhibition; Reactive Oxygen Species (ROS); Cytotoxicity; Pharmacodynamics; Pharmacokinetics; Structure–Activity Relationship (SAR); Cardiotoxicity; Apoptosis; Lip