Abstract

A REVIEW ON HYDROTROPIC SOLUBILIZATION TECHNIQUES

*Ms. Sadhana Vaidya, Ms. Kashish Thakur, Ms. Pallavi Londe, Ms. Saloni Naik, Mr. Adeshkumar Meshram

ABSTRACT

Improving the solubility of poorly water-soluble drugs remains a major challenge in both the early screening of new chemical entities and in drug formulation research. Among the various techniques available to enhance aqueous solubility, hydrotropic solubilization stands out as a promising approach. Hydrotropes are compounds that help dissolve hydrophobic drugs in water without the issues typically associated with traditional surfactants—such as emulsification problems. One of the key advantages of hydrotropes is their ability to be reused, along with the ease of recovering the dissolved drug. These features make hydrotropy particularly attractive for large-scale or industrial applications. Additional benefits like pH-independent solvent action, high selectivity, non-flammability, low cost, and wide availability further strengthen its appeal over other solubilization methods.

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