Abstract

CHARACTERIZATION AND ACTIVITY PREDICTION OF SOME HYDROXYTRIAZENES BY PASS

*Dr. G.P Singh, Dr. Ritu Tomar, Dr. R.S. Chauhan and Dr. A. K. Goswami

ABSTRACT

Computer aided drug designing has recently attracted attention of synthetic organic chemists. PASS (Prediction of Activity Spectra for Substances) is a very simple tool for prediction probable activity theoretically on the basis of molecular structure. In the present investigation hydroxytriazenes namely 3-Hydroxy-3-phenyl-1-psuphonato(sodium salt) phenyltriazene (HPST) and 3-hydroxy-3-mtolyl-1-p-sulphonato (sodium salt) phenyltrizene have been synthesized and Their chemical structure was confirmed by physicochemical method. Synthesized compounds have been screened using PASS (http://www.195.172.207.233/PASS) for probable activities and good antiviral activities along with number of other activities have been predicted. However these have to be validated by experimental bioassay.

Keywords: Hydroxytriazene, Sulphonato (sodium salt) Phenyl Triazene, PASS and Activity prediction.