Abstract

A COMPARATIVE LITERARY, ANALYTICAL, PHARMACOLOGICAL AND CLINICAL EVALUATION OF 500 MG POLYHERBAL FORMULATION (2) CAPSULE FOR DIABETES MANAGEMENT; PHYTOCHEMICAL PROFILING, MECHANISTIC INSIGHTS, AND THERAPEUTIC EFFICACY

*Dr. Ravi Raj, Dr. Pramod Bhardwaj, Dr. Naveen Aggarwal

ABSTRACT

Understanding Diabetes Mellitus and Its Ayurvedic Perspective Diabetes Mellitus has been recognized as a major health issue since ancient times, affecting people across all regions and civilizations. It is a complex metabolic disorder characterized by persistently elevated blood sugar levels, which occur either due to insufficient insulin production, resistance to insulin, or a combination of both. In today’s world, the number of people living with diabetes has risen dramatically—largely driven by modern sedentary lifestyles and unhealthy dietary habits. In Ayurveda, this condition is identified as ―Madhumeha, a specific form of ―Prameha.‖ It arises from an imbalance in the Kapha dosha, disturbances in Medo dhatu (fat metabolism), and a weakened Agni (digestive fire). These internal disruptions slow down the body’s metabolic processes, ultimately paving the way for disease. By viewing Madhumeha through the Ayurvedic lens, one gains a more holistic and integrative understanding of both its root causesand its management. According to recent data from the International Diabetes Federation (IDF), approximately 72.9 million people in India are currently living with Diabetes Mellitus. Ayurvedic texts describe Madhumeha as a Vataja Prameha, where the urine becomes sweet in taste. The disorder develops due to a long-standing imbalance of Vata dosha, impaired Medo dhatu, and disturbed Agni, closely resembling Type 2 Diabetes Mellitus as understood in modern medicine. A clinical study involving 130 individuals reported classic symptoms such as generalized body ache, sweet taste in the mouth, burning sensation in the feet, increased hunger and thirst, frequent urination, and elevated stress levels. After thorough clinical assessment and laboratory investigations, all participants were diagnosed with Madhumeha—corresponding to Type 2 Diabetes Mellitus in modern terms. In Ayurveda, this condition is categorized under Prameha, a chronic disorder affecting the body’s metabolism and energy regulation. Integrative Ayurvedic Management of Diabetes Each participant in the study received a 500 mg Polyherbal Formulation (2) Capsule for Diabetes Management for Diabetes Management, taken twice daily—once before breakfast and once before dinner. Along with the herbal therapy, patients were also guided on personalized dietary adjustments and healthy lifestyle practices suited to their individual needs. Regular follow-ups were conducted every 7 days over a period of 60 days to monitor progress and make necessary adjustments. By the end of the first month, 65 patients out of 80 patients, approximately 80% , began to experience noticeable improvements - such as reduced fatigue, better energy levels, fewer symptoms, and overall enhanced well-being. These positive outcomes continued to strengthen throughout the study, demonstrating that combining Ayurvedic herbal support with nutrition and lifestyle modification can be a powerful and effective approach to diabetes management. At the end of the trial, the use of two 500 mg capsules daily resulted in a statistically significant improvement in blood sugar levels (P < 0.005) which states that HBA1c reduced from 9 to 6.5 fasting sugar dropped from 150mg/dl to 98 mg/dl and post prandial Sugar dropped from 220 to 110-120 mg /dl mg/dl to This finding highlights the potential of Ayurvedic, plant-based therapies as a safe, natural, and holistic way to support Type 2 Diabetes Mellitus—focusing not only on symptom control but also on restoring balance within the body.

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