Abstract

SIMILARITIES AND DIFFERENCE BETWEEN US DMF, CANADIAN DMF AND EDMF

S. Santhosh Kumar Reddy*

ABSTRACT

Purpose: The submission of a DMF is not required by law or FDA regulation, it is submitted solely at the discretion of the DMF holder. The DMF contains factual and complete information on a drug product's chemistry, manufacture, stability, purity, impurity profile, packaging, and the cGMP status of any human drug product. The present work gives the Detailed idea on how to file Drug Master File in US, EUROPE, CANADA, AUSTRALIA. Approach: A Drug Master File is a submission of information to the FDA to permit the FDA to review this information in support of a third party's submission without revealing the information to the third party. In US, DMF filing was done through NDA for drugs, ANDA for generics and BLA for Biologics. In Europe, DMF filing was done through MAA via centralized procedure for eligibleproducts and for other products via decentralized procedure was used. In CANADA, DMF filing was done through NDS for both drugs and biologic products, where as in AUSTRALIA different application processes and regulatory requirements apply depending on the type of therapeutic goods that is applied. Findings: This gives you clear vision on how to file Drug master file in US, EUROPE, CANADA and AUSTRALIA. This paper also gives you the comparison of DMF fling procedure in the above-mentioned countries so that reader can have clear idea on how to file DMF and different concerns on DMF among the above counties. Conclusion: The DMF contains factual and complete information on a drug product's chemistry, manufacture, stability, purity, impurity profile, Packaging and the cGMP status of any Drug product for humans. The content and the format for Drug Master File is used to obtain marketing Authorization. The main objective of the DMF is to support regulatory requirementsArticle Received on 15 Nov. 2025,Article Revised on 05 Dec. 2025,Article Published on 10 Dec. 2025,https://doi.org/10.5281/zenodo.17877643*Corresponding AuthorS. Santhosh Kumar ReddyIndia.How to cite this Article: S. Santhosh Kumar Reddy*. (2025). SIMILARITIES AND DIFFERENCE BETWEEN US DMF, CANADIAN DMF AND EDMF. World Journal of Pharmacy and Pharmaceutical Sciences, 14(12), 1396–1429.This work is licensed under Creative Commons Attribution 4.0 International license.WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCESISSN 2278 – 4357 Impact Factor 8.025Volume 14, Issue 12, 1396-1429 Review Article Coden USA: WJPPAJwww.wjpps.com │ Vol 14, Issue 12, 2025. │ ISO 9001:2015 Certified Journal │Reddy. World Journal of Pharmacy and Pharmaceutical Sciences1397of a medicinal product to prove its quality, safety and efficacy. This helps to obtain a marketing authorization grant. Now from 2016 onwards most of the regulated countries will use eCTD or their electronic format for their DMF submission.

Keywords: DMF, FDA, CDR, CMC, CEP, LOA, TGA, ACPM, ACSOM, NDS, MAA, ANDA A Drug Master File (DMF) is a submission to the Food and Drug Administration (FDA) that may be used to provide confidential detailed information about facilities, processes, or articles used i