Abstract

CHARACTERIZATION OF BACLOFEN NON-PROPELLANT TOPICAL FOAM FOR TREATMENT OF NEUROPATHIC PAIN

Parthiban S., Chiranth Gowda B. C.*

ABSTRACT

To evaluate Baclofen non-propellant foams for physicochemical properties, stability, compatibility, and drug release for topical delivery. Baclofen was characterized by melting point, UV–vis spectroscopy, and calibration curves. FTIR assessed compatibility with excipients (SLS, HPMC, Carbopol). Foam formulations were evaluated for stability, expansion, retention, pH, drug content, moisture, and in-vitro release; release kinetics were analysed using standard models. Baclofen was pure and compatible with excipients. Optimized foams showed stable expansion, good retention, uniform drug content, skin-compatible pH, and sustained drug release via diffusion and polymer relaxation. The foams exhibited favourable physicochemical properties, stability, and sustained release, supporting their potential as effective topical formulations.

Keywords: Baclofen, non-propellant foam, Pre-formulation, FTIR, Drug release, Topical delivery.