World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , Indian Science Publications , SOCOLAR, China , NewJour-Georgetown University Library, USA , eGranary Digital Library, USA , CAS (A Division of American Chemical Society) USA , VIKAS PSOAR (Pharmaceutical Sciences Open Access Resources) , Urlich's Periodicals Directory, Proquest, UK , AYUSH RESEARCH PORTAL , Scopus ((Elsevier Products in process) , EMBASE (Elsevier Products, in process) , EBSCO Publishing Inc (Academic Search Complete, USA, In Process) , Genamics JournalSeek (In Process) , Kaohsiung Medical University Library (In Process) , OurGlocal (In Process) , eSci Research, International Research Organization. , Geneva Foundation for Medical Education and Research, Switzerland (In Process) , Thomson Reuters, USA (in process) , Polish Scholarly Bibliography , Virtual Library Pharmacy, Medicine and Health, Biosciences , Global Impact Factor (0.629) , UDLedge Science Citation Index , International Impact Factor Services , Directory of Research Journal Indexing (DRJI) , Universal Impact Factor (1.0408) , International Scientific Indexing, UAE , SJIF - Scientific Journal Impact Factor (2.786) , Scholar Steer, (Under Process) , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , InfoBase Index (In Process) , Scholar Article Impact Factor, SAIF , Citations Impact (Under Process) , CiteFactor , Journal Index (JI, Under Process) , Indian citation Index (ICI) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Eurasian Scientific Journal Index (ESJI) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Journalseek Database , IP Indexing (IP Value 2.76) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , International Scientific Indexing ( ISI ) , Scope Database , Open Access Journal , Academia , Doi-Digital Online Identifier , ISSN National Centre , Zenodo Indexing , International CODEN Service, USA ,

World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

Login

Search

News & Updation

Updated Version

WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

Call for Paper

WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

STUDY OF ANTI-HISTAMINIC AND MAST CELL STABILIZING ACTIVITY OF HYDROETHANOLIC EXTRACT OF SHIRISHADI – A POLYHERBAL AYURVEDIC COMPOUND

Kajaria Divya*¹, Tripathi. J.S.¹, Tiwari. S.K. ¹, Pandey. B.L.²

¹Dept. of Kayachikitsa, Faculty of Ayurveda, Institute of Medical Sciences, B.H.U.- 221005, Varanasi, India.

²Dept. of Pharmacology,Institute of Medical Sciences, B.H.U.-22005,Varanasi, India.

ABSTRACT

Shirishadi Compound is an Ayurvedic polyherbal preparation used in Indian traditional medicine for the treatment of Asthma & allergic disorders. The pharmacodynamic properties of ethanolic extract of Shirishadi compound was evaluated on experimental model for its antihistaminic property against H1 receptor and mast cell stabilizing property. Significant increase in preconvulsion time was observed on pretreatment with Shirishadi compound when the guinea pigs were exposed to histamine. Demonstration of graded dose response of histamine and its competitive antagonism on isolated perfused guinea pig ileum shows that it has specific antagonism. The increasing dose of Shirishadi showed the Tachyphylaxis and receptor protection response. The present study revealed that the ethanolic extract of Shirishadi compound has significant antihistaminic (H1 receptor antagonism) activity. Polyherbal formulation (500μg and 1000μg/ml) showed dose dependent significant reduction in mast cell degranulation (P

Keywords: Shirishadi compound, Antihistaminic activity, Mast cell stabilizing effect.

[Download Article] [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Downloads

Author Instruction

Covering Letter

Copyright Form

Apycom jQuery Menus