Abstract

SOLUBILITY ENHANCEMENT OF ACECLOFENAC USING LIQUISOLID COMPACT TECHNIQUE

Shweta Vijaywargiya*, Dr. Ravi Kant Sharma

ABSTRACT

Liquisolid compact technique is a novel concept for delivery of drug through oral route. This approach of delivering drug is mostly suitable for lipophilic drug and poorly or water insoluble drugs. The main objective of present study was to increase the solubility of water in soluble BSc class II drug aceclofenac. Aceclofenac is alipophilic drug that is practically insoluble in water and exhibit an excessively slow dissolution rate in class II compound in biopharmaceutics classification system. The liquid solid compacts were prepared using PEG 400 as non volatile solvent, microcrystalline cellulose as carrier, aerosil 200 as coating material and Sodium starch glycolate was used as super disintegrating agent. Several formulations of liquid solid compacts having different drug concentration in PEG 400 (non volatile solvent) with varying ratio of career to coating material were prepared. The liquid solid compacts were evaluated for Bulk characterization, Flowproperties, solubility studies, drug content, FTIR studies, and in vitro drug release studies. The saturated solubility studies and in vitro drug release studies shows that the increase in solubility of drug and enhanced drug release rate in liquisolid compacts compared to pure drug. The Formulation F5 and F4 is considered as best formulation as it has shown highest drug release in short time (1 hr). Our studies showed that the solubility of the drug can be significantly enhanced with increase in the carrier content there is increase in the solubility resulting and enhanced drug release rate.

Keywords: Liquisolid compacts, Aceclofenac, carrier material, coating material Solubility enhancement, in vitro drug release.