Abstract

A REVIEW ON POLYHERBAL ANTIFUNGAL CREAM

*Mahesh Gokul Shinde, Priya Pankaj Wakchaure, Priyanka Jalinder Kaitke, Ms. Jayashri Kasar

ABSTRACT

The aim of this work is to formulate and evaluate anti scabies cream, Scabies has been scourged among human beings for thousands of years. It's worldwide occurrence with epidemics during war, famine and overcrowding which is responsible for an estimated 300 million peoples currently infested. It is also greatest impact on children. Scabies refers to various skin infections. Long-term scabies disease can lead to complications such as septicemia, acute post-streptococcus glomerulonephritis, heart disease, and secondary infections. Timely treatment to the affected patients is required to control the disease and get rid of the causative agent. Method: The cream formulation was designed by using pongamia pinnata leaves, neem oil, steric acid, potassium hydroxide, sodium carbonate, white soft paraffin, methyl alcohol, glycerin, methyl paraffin and required amount of rose oil or distilled water. The skin pH, maintained by drop wise addition of try-ethanolamine. The prepared cream was evaluated for physical appearance, pH, skin irritation to observed side effect. It was inferred from the result that cream formulation were good in appearance and homogeneity. The overall result of the research the prepared cream formulation shows significant anti-fungal activity. The antifungal cream is assessed utilizing a variety of chemical and physiological assays. Information on numerous formulation parameters is provided by these tests, the tests' findings were documented. Numerous secondary metabolites were examined, such as phytosterols, alkaloids, glycosides, flavonoids, saponins, tannins, and phenolic substances. The oil phase of the cream base consisted of stearic acid, potassium hydroxide, sodium carbonate, white soft paraffin and rose oil. The aqueous phase consists of methanol extract of Pongamia pinnata, glycerin, distilled water and methylparaben. The characterization of the formulated cream was carried out by standard methods such as homogeneity test, pH test, irretence test and removal test.

Keywords: Cream, Neem oil, Pongamia pinnata, Skin layers.