Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF KETOROLAC IMMEDIATE RELEASE SUMATRIPTAN SUSTAINED RELEASE BILAYER TABLETS

S. Ramulu*, V. Jayanth

ABSTRACT

The present study is concerned with formulation development and evaluation of ketorolac immediate release and sumatriptan sustained release bi-layered tablet. An attempt was made to develop bi-layer tablet suitable for delivering different drugs with different release pattern like one layer of drug as immediate release to get quick relief and second drug as sustained release of drug which gives effect of drug for sufficient long time and reduce frequency of dose. In the bi-layered tablet the immediate layer were prepared by direct compression method by using super disintegrants such as cross carmellose sodium ,sodium starch glycolate and sustained layer were prepared by wet granulation method using polymers such as hydroxy propyl methyl cellulose, ethyl cellulose and pvp k-30.The prepared formulations were evaluated for their physicochemical characteristics, bulk density, tapped density, angle of repose, compressibility index, hausener’s ratio, and In vitro drug release studies . The formulation having immediate release layer produces immediate effect 98% in 60 minutes followed by sustained release effect 97.5% up to 8 hours. With the data of kinetic analysis, F9 formulation showed best linearity in Higuchi’s Equation plot indicating that the release of drug from matrix tablet follows Non Fickian diffusion.

Keywords: Bi-layered tablet, ketorolac, sumatriptan, Immediate Release, Sustained Release, Higuchi euation