Abstract

ORGANIC CHEMISTRY BEHIND AROMATHERAPY

Shafia Sultana*, Aatiqua Siddiqui, Habeeba Naaz, Khizra Siddiqui

ABSTRACT

Aromatherapy is a holistic healing practice that utilizes natural plant extracts, particularly essential oils, to promote physical and psychological well-being. This review explores the organic chemistry underpinning aromatherapy, with a special focus on the bioactive compounds responsible for its therapeutic effects. Essential oils are complex mixtures primarily composed of volatile organic compounds such as terpenes and terpenoids, which are derived from isoprene units. These compounds exhibit diverse structures and functionalities, influencing their aroma and biological activity. The review delves into the biosynthesis pathways of key terpenes and terpenoids, elucidating their roles in plant defense and human health. Mechanistically, essential oils interact with the human body through olfactory receptors and systemic absorption, triggering antioxidant, antimicrobial, andanti-inflammatory responses. A detailed case study on menthol, a major component of peppermint (Mentha piperita) essential oil, highlights its molecular structure, mode of action, and therapeutic effects on the respiratory, nervous, and muscular systems. This article bridges the gap between traditional aromatherapeutic practices and modern organic chemistry, providing a scientific lens through which the efficacy of essential oils can be understood and appreciated.

Keywords: Aromatherapy, Essential oil, terpenes, terpenoids, isoprene unit, olfactory receptors, antioxidant, anti-inflammatory, antimicrobial.