Abstract

AN OVERVIEW OF ALTERNANTHERA SESSILIS LEAVES

Ramesh H. A., Bhavya V.H.*, Ranjitha D. E., Kruthi S., Rohith R.

ABSTRACT

It is Commonly known as dwarf copperleaf or sessile joyweed, Alternanthera sessilis is a leafy vegetable that has long been used in Southeast Asia, India, and Sri Lanka. It is prized in traditional medicine for its laxative, cooling, diuretic, and tonic properties. It has long been used to make kajal and medicinal oils, as well as to treat eye conditions, hemorrhoids, and dysuria. Its medicinal potential has been validated by recent research. When rats were exposed to gentamicin, the ethanolic extract of A. sessilis (EEAS) demonstrated nephroprotective effects. With protective effects similar to those of vitamin E, EEAS dramatically reduced blood creatinine, uric acid, and BUN at dosages of 100–200 mg/kg while raising levels of protein, albumin, and globulin. Kidney protection was further validated by histological studies. Additionally, in albino rats, the ethanol extract of aerial portions had antipyretic properties as effective as paracetamol, lowering both normal and yeast-induced fever in a dose-dependent manner (200–400 mg/kg). These findings highlight its nephroprotective and antipyretic properties while validating its traditional uses.

Keywords: Alternanthera sessilis, antipyretic, ethanolic extract.