Abstract

DEVELOPMENT AND COMPARATIVE EVALUATION OF ALLOPOLYHERBAL FORMULATION COMPRISING HERBAL EXTRACTS FOR DIABETES MANAGEMENT

Prakash D. Jadhav*, Vidya B. Jagtap, Sangram S. Madane Atish B. Velhal, Ashish T. Thorat

ABSTRACT

Diabetes mellitus is a chronic metabolic disorder that demands long-term therapy, with conventional synthetic drugs often associated with adverse effects and limited efficacy. The present study aimed to develop and evaluate an allopolyherbal formulation comprising standardized herbal extracts of Trigonella foenum-graecum (fenugreek), Azadirachta indica (neem), Cinnamomum verum (cinnamon), Tinospora cordifolia (guduchi), Curcuma longa (turmeric), and Piper nigrum (black pepper) in combination with metformin. These plants are well recognized for their antidiabetic, antioxidant, and metabolic regulatory effects. Formulations were developed by direct compression method and subjected to preformulation and post-compression evaluations including compatibility studies (FTIR, DSC), micromeritic properties (angle of repose, bulk/tapped density), tablet hardness, friability, disintegration,drug content, and in-vitro dissolution profiling. Results confirmed compliance with pharmacopeial standards for immediate-release tablets. In-vitro dissolution studies demonstrated satisfactory drug release, with the allo-polyherbal formulation showing superior dissolution compared to polyherbal-only formulations, suggesting synergism between herbal extracts and metformin. The findings support the potential of allo-polyherbal therapy as a dose-sparing strategy for metformin while enhancing therapeutic efficacy and minimizing adverse drug reactions.

Keywords: Diabetes mellitus, Allopolyherbal formulation, Metformin, Herbal extracts, Immediate-release tablets.