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REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ACYCLOVIR IN BULK AND PHARMACEUTICAL DOSAGE FORM
Swathi K.*, Hamsa T., Priyadarshini H. N., Priyanka A., Kruthik P.
ABSTRACT Acyclovir was granted FDA approval on 29 March 1982 to treat genital herpes and HSV encephalitis and it belongs to the family of antiviral drug. The review highlights the variety of analytical methods such as UV spectroscopy, high performance liquid chromatography (HPLC), GC (Gas chromatography), LCMS and High performance thin layer chromatography (HPTLC) and also mobile phase, mobile phase ratio, column, retention time, flow rate and wavelength of UV detector, run time and Validation parameter is Linearity, percentage recovery, limit of detection and limit of quantification for the estimation of Acyclovir in pharmaceuticals. The present work categorical the new easy, accurate, precise analytical methodology for the determination of Acyclovir in bulk and pharmaceutical Dosage Forms. Keywords: Acyclovir, UV, HPLC, UPLC, HPTLC. [Download Article] [Download Certifiate] |
