Abstract

SYNTHESIS OF SOME 5, 6-DIPHENYL-IMIDAZO [2, 1-B] OXAZOL- 3(2H) ONE DERIVATIVES

Vivek Gupta*, Rakesh Patel, Ravindra Patidar, Deepti Joshi

Charak Institute of Pharmacy, Mandleshwar Dist. Khargone (M.P.) India.

ABSTRACT

The work aims at better imidazole phamacophore as both the reactant used in synthesis have their own biological activity. 5, 6-diphenylimidazo [2, 1-b] oxazol-3(2h) one derivatives are prepared with the help of chemicals such as benzoin , urea, choloroacetic acid ,fused sodium acetate , acetic anhydride ,glacial acetic acid , 4-chloro benzaldehyde, 3-4 dihydroxy benzaldehyde and anisaldehyde. The present study reports the synthesis of some novel substituted imidazoles. The synthesized compound were recrystalized and identified by TLC, the Rf values were calculated. The melting point of the product were found and presented uncorrected. Structure of synthesized compound is confirmed by IR, NMR & Mass spectroscopy. The entire synthesized compound screened for antimicrobial activity. The substituted imidazol derivative have wide spectrum of pharmacological activity hence further structural modifications and screening has to be done to confirm the more and still better activity.

Keywords: Phamacophore recrystalized, Melting point, Spectrum.