Abstract

A COMPREHENSIVE REVIEW OF VITAMIN C CHEMISTRY AND ITS FUNCTIONAL DERIVATIVES”

S. S. Chhajed*, Z. I. Kazi, N. M. Bhatlondhe, S. K. Khinde and S. M. Ahire

ABSTRACT

L-Ascorbic acid (ASA), or vitamin C, plays an essential role in cellular processes such as collagen synthesis, cellular oxidation, inhibition of melanogenesis, and various hydroxylation reactions. It is also involved in the synthesis of neurotransmitters like dopamine, noradrenaline, and adrenaline, and helps protect cells from oxidative damage caused by free radicals and reactive oxygen species. ASA is widely used in topical products for its UV protection, skin brightening, toning, firming, and tightening effects. However, it is unstable in aqueous systems due to oxidation, reducing its effectiveness. To overcome this, various prodrugs and derivatives have been developed that release active ascorbic acid in the skin. These forms are more stable and suitable for skin application, enabling the development of effective formulations with added benefits.

Keywords: L-Ascorbic acid, Antioxidants, Collagen synthesis, UV Protection.