Abstract

ANTIVIRAL SOLID LIPID NANOPARTICLES: NEXT- GEN FORMULATIONS FOR PANDEMIC PREPAREDNESS – A COMPREHENSIVE REVIEW

B. Premkumar*, P. R. Roshan Khumaar, K. Samunesh, D. Keshika, M. Pradeepkumar, K. Karthick, G. Saroj, M. D. Swetha and S. Mohamed Shehal

ABSTRACT

The emergence of viral pandemics such as COVID-19, Ebola, and Influenza has underscored the need for advanced drug delivery systems that offer enhanced efficacy, stability, and scalability. Solid Lipid Nanoparticles (SLNs), a class of nanocarriers composed of biocompatible lipids, have emerged as a promising platform for antiviral drug delivery. This review delves into the formulation strategies, physicochemical attributes, mechanisms of action, and advantages of antiviral SLNs. We also explore recent advances, preclinical outcomes, and translational challenges while emphasizing their potential role in global pandemic preparedness and rapid-response systems.

Keywords: Solid Lipid Nanoparticles, Antiviral Nanomedicine, Lipid-based Nanocarriers, Pandemic Preparedness, Drug Delivery Systems, COVID-19, Viral Infections.