Abstract

FORMULATION AND EVALUATION OF PH-TRIGGERED IN SITU NASAL GEL OF DEXIBUPROFEN

Jayaseelan H.*, Dr. G. Mariyappan, Dr. J. Karthi and Prakash Murugan

ABSTRACT

The goal is to enhance Dexibuprofen's solubility, mucosal adhesion, and controlled release to ensure efficient nasal drug delivery, the current study intends to develop and evaluate pH-sensitive in-situ nasal gels. a combination of ethanol and phosphate buffer (pH 6.4) as co-solvents greatly increased the solubility of dexibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) with low water solubility. Compatibility was ensured by FTIR spectroscopy, which confirmed that Dexibuprofen and the excipients did not interact chemically. Carbopol 934P and HPMC K4M were used in varying ratios to create five nasal gel formulations (F1–F5), which had been chosen for their mucoadhesive and controlled-release capabilities. Each of the formulation exhibited appropriate viscosity, essentially unchanged drug content (97.5%–101.2%), and positive physical properties. Higher polymer concentrations were associated which hasgreater mucoadhesive strength and viscosity. At nasal pH, the gels rapidly transformed from sol to gel, with F3 and F4 exhibiting the most powerful gels and a prolonged mucosal retention. Studies on drug release showed that polymer concentration affected sustained release, with F3 and F4 showing the most favorable release kinetics for long-lasting therapeutic benefits. For the purpose of to improve solubility and pH-triggered gelation, respectively, ethanol and phosphate buffer were essential. The most successful formulations were F3 and F4, which combined stability, strong mucoadhesion, and prolonged drug release. The potential of pH-triggered in-situ nasal gels to improve the bioavailability and therapeutic impact of poorly soluble medications, such as Dexibuprofen, will be explained by this study.

Keywords: Dexibuprofen, In-situ nasal gel, Mucoadhesive polymers, Sustained drug release, pH-triggered gelation.