Abstract

REVIEW ON IMPACT OF CHRONOPHARMACOLOGY IN OUR LIFE STYLE

Shilpi Kumari*, Rajaram R. Rajbhar*, Gopal Kumar

ABSTRACT

Chronopharmacology is a field studying the interaction between biological rhythms, like the circadian rhythm, and the pharmacokinetics (drug absorption, distribution, metabolism, and excretion) and pharmacodynamics (how drugs affect the body) of medications. It emphasizes aligning drug administration with the body's natural cycles to improve therapeutic outcomes and reduce side effects. Circadian rhythms influence drug behavior and impact systems like the immune, cardiovascular, and nervous systems, affecting drug effectiveness. For example, antihypertensive medications may work better when taken at night, and chemotherapy may be more effective when timed with tumor cell growth cycles. Antidiabetic drugs also show improved results when aligned with insulin production. Chronopharmacology aims to optimize drug treatment by considering the timing of administration, enhancing benefits while minimizing side effects. This approach, known as chronotherapy, is gaining interest inpersonalized medicine, which tailors treatment plans to individual circadian rhythms, age, and lifestyle. Though promising, chronopharmacology is still developing. More research is needed to understand its mechanisms and refine clinical guidelines for precise drug timing, with the potential to revolutionize treatment and provide safer, more effective therapies.

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