Abstract

GREEN CHEMISTRY IN THE DESIGN AND SYNTHESIS OF PHARMACEUTICALS

P. Aravanan, Dr. D. Dhachinamoorthi, S. Sivamuthali*, R. Ashika Parveen, V. P. Fathimathul Ameera, U. Selvamani and A. Elumalai

ABSTRACT

Background: Green chemistry is essential to contemporary pharmaceutical synthesis because it encourages safer and more ecologically friendly production methods. This strategy emphasizes using sustainable raw materials, decreasing harmful compounds, and increasing reaction efficiency. In drug development, novel approaches include solvent free methods, enzymatic reactions, microwave assisted procedures, and continuous flow chemistry are becoming more and more popular as environmentally friendly substitutes. Aim: These methods aim to improve product yields and purity while reducing waste production and energy use. Furthermore, the use of instruments like E factor and atom economy to evaluate and enhance the environmental performance of synthetic processes is growing. Methods: Methods included to promote environmental sustainability are catalysis in drug synthesis, microwave assisted organic synthesis, flow chemistry etc. Results: Green chemistry concepts in pharmaceutical manufacture guarantees legal compliance and financial gains as the need for more environmentally friendly production persists. In addition to promoting environmental sustainability, the use of green chemistry concepts in pharmaceutical manufacture guarantees legal compliance and financial gains. Collaboration between researchers, industry stakeholders, and policymakers is crucial for the progress and integration of green techniques in drug synthesis, since the demand for greener production keeps growing. Conclusion: One of the major benefits of using green chemistry in drug production lies in its capacity to significantly reduce the environmental footprint of manufacturing. Traditional methods often depend on harmful solvents, excessive chemical inputs, and high energy consumption. In contrast, sustainable strategies like bio catalysis, microwave and ultra sound assisted reactions, mechanochemistry, and flow chemistry limit the formation of unwanted byproducts and make better use of materials and energy.  

Keywords: Green chemistry, biocatalysis, pharmaceutical production, sustainable synthesis, and ecologically friendly reaction.