Abstract

PIPER LONGUM LINN.: A REVIEW ON CUSTOMARY APPLICATIONS, PHARMACEUTICAL NOVEL DRUG DELIVERY SYSTEM, PHARMACOLOGICAL AND THERAPEUTIC ACTIVITIES FOR FUTURE TRANSLATIONAL RESEARCH

*Saravana Kumar M., D. Dhachinamoorthy, B. Premkumar, Shana, Afeefa Sherin, Souraj, Murshid and Mohammed Irfan

ABSTRACT

Piper longum Linn., known as “long-pepper” or “Pippali” grows as a perennial shrub or as an herbaceous vine. It is native to the Indo-Malaya region and widely distributed in the tropical and subtropical world including the Indian subcontinent, Sri Lanka, Middle-East, and America. The fruits are mostly used as culinary spice and preservatives and are also a potent remedy in various Traditional evidence medicinal systems against bronchitis, cough, cold, snakebite, and scorpion-sting and are also used as a contraceptive. Various bioactive-phytochemicals including alkaloids, flavonoids, esters, and steroids were identified from the plant extracts and essential oils from the roots and fruits. As per the customary applications and literature review of these plants pharmacological activities were reported as antimicrobial, antiparasitic, anthelminthic, anti-inflammatory, analgesic, antioxidant, Neuroprotective, antihyperglycemic, hepatoprotective, antihyperlipidemic, immunomodulatory, antiarthritic, antiulcer, antiasthmatic, cardioprotective, and anti-snake-venom agents. The phytochemistry, and pharmacology of Piper longum Linn.in relation to its medicinal importance and health benefits to validate the traditional claims supported by specific scientific experiments. In addition, it also discusses the safety and toxicity studies, application of green synthesis and nanotechnology as well as clinical trials performed with the plant also elucidating research gaps and future perspectives of its multifaceted uses. novel drug delivery technology refers to the approaches, antihyperlipidemic, immunomodulatory, antiarthritic, antiulcer, antiasthmatic, cardioprotective, and anti-snake-venom agents. The phytochemistry, and pharmacology of Piper longum Linn.in relation to its medicinal importance and health benefits to validate the traditional claims supported by specific scientific experiments. In addition, it also discusses the safety and toxicity studies, application of green synthesis and nanotechnology as well as clinical trials performed with the plant also elucidating research gaps and future perspectives of its multifaceted uses. novel drug delivery technology refers to the approaches, 

Keywords: Piper longum Linn.; Customary Applications; Novel drug delivery technology; Pharmacological and Therapeutic activities.