Abstract

DETERMINING THE COUNTERACTING AND AMELIORATING EFFECT OF VITAMIN B-COMPLEX ON THE LIVER OF METHAMPHETAMINE INTOXICATED ADULT MALE WISTAR RATS

Okafor Emeka Christian*, Ezeokafor Emmanuel Nonso, Nnaemeka Wuraola Serah, Ifegwu Njoku Oji, Dr. Ajaegbu Obinna Chinedu and Umeanozie Kosisochukwu Janet

ABSTRACT

This study was carried out to determine the counteracting and ameliorating effect of vitamin B-complex on the liver of methamphetamine-intoxicated adult male Wistar rats. Twenty-eight (28) adult male Wistar rats were randomly assigned into seven groups (A–G) of 4 rats each. Group A served as control; Group B received vitamin B-complex only for 21 days; Group C received methamphetamine only for 21 days; Group D received methamphetamine and vitamin B-complex concurrently for 21 days; Group E received vitamin B-complex for 21 days before methamphetamine for another 21 days; Group F received methamphetamine for 21 days followed by vitamin B-complex for 21 days; and Group G received distilled water only. Liver tissues were harvested and subjected to histological examination. Results showed significant hepatic damage in the methamphetamine-only group, while groups treated with vitamin B-complex showed varying levels of liver recovery. The study supports the hepatoprotective role of vitamin B-complex against methamphetamine-induced liver toxicity.

Keywords: Vitamin B-complex, Methamphetamine, Liver, Wistar rats, Hepatotoxicity, Histology.