Abstract

FORMULATION AND EVALUATION OF RIFAMPICIN FAST DISSOLVING TABLET

Ch. Srinivas Reddy, G. Babu*, G. Mayuri

ABSTRACT

Rifampicin is water insoluble oral antimicrobial agent, with problems of variable bioavailability and bioequivalence related to its water insolubility. It is administered orally as the inactive prodrug Rifampicin which is rapidly and completelyconvert to Rifampicin during gastrointestinalabsorption. Rifampicin should be administrated 10mg/kg daily 0r 2-3 times weekly. Max; 600 mg/day. In this investigation rapid disintegrating tablet were prepared by using super disintegrating agent; crospovidon, crosscaremellose sodium, sodium starch gycolate in concentration 3%,6%,9%. Sweeteners and flavours were used to enhance the organoleptic properties of tablet. Tablets were prepared by direct compression technique. Prepared tablets were evaluated for thickness, uniformity of weight, hardness, friability, wetting time, in-vitro disintegration time, drug content and in vitro drug release. Disintegration time and drug release were taken as the basis to optimize the rapidly disintegrating tablet. All the formulations were evaluated for the influence ofdisintegrates and their concentrations on the characteristics of rapid disintegrating tablets mainly in terms of disintegration time and dissolution studies. The disintegration time of all formulation showed less than 38 seconds. Among the three superdisintegrants used, Crospovidon showed less disintegrating time followed by crosscarmellose sodium and sodium starch gycolate. The relative efficiency of different superdisintegrants to improve the drug rate of tablets was in order, crospovidon> Crosscarmellose sodium >sodium starch gycolate.

Keywords: Rapid disintegrating tablet, superdisintegratants, Rifampicin, crospovidon, Crosscarmellose sodium, sodium starch gycolate.