Abstract

FORMULATIN AND EVALUATION OF SILYMARIN NANOPARTICLES TABLET

Anand Kumar* and Namrata Mishra

ABSTRACT

The objective of this work was to formulate and evaluate with optimized formulation of silymarin by developing and refining a tablet formulation loaded with nanoparticles. Formulation development and optimization of silymarin-loaded nanoparticle tablet for its anti-inflammatory activity is the focus of this research paper. Nanoparticle drug delivery systems can help to overcome these limitations by enhancing solubility and absorption. Disintegration and dissolution of tablets take place in the mouth rapidly without water, providing a faster onset of action. These nanoparticles were then incorporated into tablets containing super-disintegrants and sweeteners using direct compression. A Box-Behnken design was utilized to systematically optimize the tablet formulation based on responses including disintegration time, wetting time, hardness and friability. Overall, the development of silymarin nanoparticle ablets shows promise for improving the anti-inflammatory effects of silymarin through a synergistic combination of nanoencapsulation and rapid disintegrating tablet technologies.

Keywords: Silymarin tablets, Rapid dissolving, Anti-inflammatory activity, Nanoparticles, Optimization.