Abstract

DRUG-INDUCED SYNDROME OF INAPPROPRIATE ANTI-DIURETIC HORMONE SECRETION: A CASE REPORT

Niharika Bhuyyar*, Lakshmi L., Gourish Patil and Viju Hulkund

ABSTRACT

Syndrome of Inappropriate Anti-diuretic Hormone Secretion (SIADH) is a condition characterized by impaired water balance regulation, leading to hyponatremia and hypo-osmolality. This condition results from excessive secretion or action of anti-diuretic hormone (ADH), which causes water retention and dilutional hyponatremia. While SIADH has multiple etiologies, drug-induced cases remain under-recognized despite their clinical significance. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, and anticonvulsants have been implicated in altering renal water and sodium handling, contributing to this disorder. Case presentation: - Here, we report a case of acute symptomatic SIADH in a 52-year-old female triggered by the use of aceclofenac, an NSAID prescribed for shoulder pain. The patient presented with symptomatic hyponatremia and was successfully managed with hypertonic saline and fluid restriction after discontinuation of the offending drug. Conclusion:This case underscores the importance of identifying medication-induced SIADH as a reversible cause of hyponatremia and highlights the need for clinicians to remain vigilant in recognizing and managing this potentially life-threatening condition in a timely manner.

Keywords: SIADH, Hyponatremia, NSAIDs, Anti-diuretic hormone, Aceclofenac.