Abstract

NASAL DRUG DELIVERY SYSTEM: A REVIEW

Prajakta Chavan1*, Shashikant Dhole, Mayuri Yada

ABSTRACT

Nasal drug administration has been used as an alternative route for the systemic availability of drugs restricted to intravenous administration. This is due to the large surface area, porous endothelial membrane, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including numerous compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in rapid systemic drug absorption. Certain drugs are delivered to the nasal cavity because their intended site of action. These are administrated as nasal drops or sprays for a local effect. Such drugs in clinical use include decongestants, antibiotics and mucolytics.

Keywords: Nasal drug delivery system, bioavailability, nasal cavity, nasal absorption, nasal route.