Abstract

EFFECT OF PEEL EXTRACT OF PUNICA GRANATUM GEL AS LOCAL DRUG DELIVERY IN PERIODONTITIS SUBJECTS

Dr. Arati C. Koregol, Dr. Nagaraj B. Kalburgi, Dr. Uzma Parveen Sulthana* and Dr. Anjaly Roy

ABSTRACT

Background: Chronic multifactorial inflammation known as periodontitis is linked to dysbiotic plaque biofilms and is characterised by the progressive loss of the structures that support teeth. In order to treat periodontal disease, natural therapies are currently gaining favour over synthetic ones. Punica granatum, which is regarded in ayurvedic medicine as “a pharmacy unto itself.” Punica granatum peel extract (PGPE) has exhibited topical anti-inflammatory and analgesic properties through inhibiting the leukocyte infiltration and modulating the proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha, in addition to antimicrobial and antioxidant properties. Objectives: To evaluate, compare and correlate clinical parameters at baseline and 21st day after scaling and root planning (SRP) alone and after placement of PGPE gel. Methodology: A total of 80 subjects with chronic periodontitis were selected. Participants were divided into 2 groups, group A and B. Group A, SRP alone (40) in Group B, SRP plus local drug delivery with PGPE gel at selected sites (40). Gingival index, Plaque index, Pocket Probing Depth(PPD), Clinical attachment loss (CAL), Periodontal disease index (PDI) was recorded at baseline and 21st day. Results: Statistically significant difference in PI, GI was found at baseline and 21 days in both Group A and B. Analysing PPD and PDI the intergroup comparison revealed maximum reduction being seen in group B from baseline to 21days (p < 0.001). On analysing CAL revealed reduction in group B compare to that of Group A with statistically significant (p < 0.090). Conclusion: Punica granatum peel extract gel as local drug delivery is an easy, non-invasive, cost-effective, advantageous method, beneficial in reducing Periodontal probing depth and clinical attachment loss along SRP in periodontitis subjects.

Keywords: Local drug delivery, Periodontitis, CAL, Pocket probing depth, Anti-oxidant.