Abstract

FROM SOLUBILITY ENHANCEMENT TO DRUG DELIVERY: THE EXPANDING ROLE OF IONIC LIQUIDS IN PHARMACEUTICS

Sofiya Firoj Mujawar*, Deep Madhukar Chaudhari, Siddhesh Vishnu Rokade, Vinayak Vithoba Rasal, Jagdish Vijay Jadhav and Nandini Pramod Dolase

ABSTRACT

For newly created or commercialized therapeutic compounds, creating efficient medication formulations and delivery methods continues to be a major problem. These medications may have systemic toxicity, polymorphic conversion, and poor absorption. Because of their acute toxicity, they may also be challenging to synthesize using conventional organic solvents. It has been known that ionic liquids (ILs) are solvents that can enhance a drug's pharmacokinetic and pharmacodynamic characteristics. The functional and operational issues with conventional organic solvents can be resolved by ILs. However, the biggest obstacle to creating IL-based medication formulations and delivery methods is that many ILs are intrinsically hazardous and non-biodegradable. Biocompatible ILs are regarded as an environmentally friendly substitute for traditional ILs and organic or inorganic solvents since they include biocompatible cations and anions that are mostly sourced from bio-renewable sources. The technologies and approaches used to create biocompatible ILs are reviewed in this study, with an emphasis on creating biocompatible IL-based medication formulations and delivery systems. The benefits of these ILs in pharmaceutical and biomedical applications are also covered. Additionally, this analysis will offer recommendations for switching from widely used organic solvents and harmful ILs to biocompatible ILs in a variety of industries, including pharmaceutics and chemical synthesis.

Keywords: Ionic liquids, Pharmacokinetic, Biomedical, Biocompatible, Pharmacodynamics.